Fatty Acids as Inhibitors of Microbial Cell Wall Synthesis

Inhibition of microbial lipases by fatty acids.

Addition of lard or sodium oleate to the medium used for lipase production by Pseudomonas fragi resulted in a decreased accumulation of lipase in the culture supernatant fluid without affecting cell growth. The production and activity of lipase was inhibited by lard, sodium oleate, and the salts of other unsaturated fatty acids. Some divalent cations, Tweens, lecithin, and bovine serum prevente...

7449 Microbial Oxidation of Unsaturated Fatty Acids

Ristocetins, inhibitors of cell wall synthesis in Staphylococcus aureus.

Inhibition of bacterial cell wall synthesis is an important mechanism of action of antibacterial agents. Bacterial cell walls are chemically and morphologically distinct from any structures found in animal cells. Inhibition of synthesis of these structures results, therefore, in selective toxicity. The antibacterial action of penicillins (1, 2), n-cycloserine (3, 4), bacitracin (5), and novobio...

Microbial fatty acids and derivatives in biotechnology

Food lipids http://www.stu.edu.vn/uploads/documents/ 030509-215944.pdf Some food lipids are obtained from microbes. This book offers a comprehensive account of food lipid chemistry and biotechnology. Antimicrobial lipids on skin http://www.jlr.org/cgi/reprint/49/1/4 This web article describes the surprising finding that a monounsaturated C16 fatty acid is the most effective antimicrobial agent ...

Novel drug targets for Mycobacterium tuberculosis: 2-heterostyrylbenzimidazoles as inhibitors of cell wall protein synthesis

BACKGROUND Multi drug-resistant and mycobacterial infections are a major public health challenge, leading to high mortality and socioeconomic burdens through worldwide. Novel therapeutics are necessary to treat the drug resistant strains, since no new chemical entities are emerged in the last four decades for the treatment of TB. FINDINGS A series of novel 2-heterostyrylbenzimidazole derivati...